This work was carried out to study the effect of the date stone meal (DSM) as unusual energy source instead of yellow corn in Nile tilapia diets on body weight, body weight gain, weight gain %, feed intake, feed conversion, carcass characteristics, feed cost and histopathological finding. Forty two Male healthy Nile tilapia (O.niloticus) were used in this study .Three approximately were is nitrogenous and isocaloric diets and formulated with date stone meal instead of yellow corn at level 0, 25, 75% respectively. The results of this experiment showed that cumulative feed consumption was affected by feeding date stone meal. The diet containing 75% date stone meal exhibited better growth performance as unusual energy source. The best dressing percentage was recorded with diet containing 75% date stone meal as compared with other groups. On the other side from the economical point of view the tilapia fed diet containing 75% DSM showed the nearly economical results in comparing with control. The histopathological examination showed histological change in group fed diet containing 75% date stone meal as compared with other groups. Using of date stone meal instead of yellow corn may give a partial solution of feed shortage and to prepare relatively cheep and balanced diet.