Cloud computing is a modern technology for dealing with large-scale data. The Cloud has been used to process the selection and placement of replications on a large scale. Most previous studies concerning replication used mathematical models, and few studies focused on artificial intelligence (AI). The Artificial Bee Colony (ABC) is a member of the family of swarm intelligence based algorithms. It simulates bee direction to the final route and has been proven to be effective for optimization. In this paper, we present the different costs and shortest route sides in the Cloud with regard to replication and its placement between data centers (DCs) through Multi-Objective Optimization (MOO) and evaluate the cost distance by using the knapsack problem. ABC has been used to solve shortest route and lower cost problems to identify the best selection for replication placement, according to the distance or shortest routes …