أعضاء هيئة التدريس - جامعة بنها
Protective effects of curcumin against Augmentin-induced hepatotoxicity in rats
• 2019
معلومات البحث
المؤلفون
M Elshemy
الكلمات المفتاحية
Not Available
المجلة العلمية
Not Available
الناشر
Not Available
المجلد
Not Available
العدد
Not Available
الصفحات
Not Available
publication.type
International
رابط البحث
Not Available
المواد المرفقة
Not Available
الملخص
البحث الخامس
( بحث فردى منشور محلى غيرمستخلص من رسالة علمية ولم يسبق تقييمه)
Protective effects of curcumin against Augmentin-induced hepatotoxicity in rats
Mona A. El Shemy1
1 Department of Clinical Pathology, Faculty of Veterinary Medicine, Benha University
Aims: Amoxycillin/clavulanic acid (Augmentin®) is an effective antibiotic which was approved by WHO as a drug for treatment of infection. Its efficacy to inhibit microorganisms had led to their increased use. There is a possibility that the drug may have potential toxic effects following consumption. So, we design this study to investigate if the Amoxycillin/clavulanic acid had toxic effects on liver or not and to explore the role of curcumin in the reduction of this toxic effect. Methods: Forty male albino rats were separated into four groups (10 rats per group); Control group, Augmentin group, curcumin group and curcumin protected group. Amoxycillin/clavulanic acid was administered at 31.83 mg/kg b.wt twice for seven days, curcumin was taken at 300 mg curcumin / kg b.wt for two weeks. Results: Amoxycillin/clavulanic acid caused a significant elevation in the level of serum malondialdehyde (53.53±0.43nmol/g). Moreover, it increased the serum ALT activity (104.87±1.01 U/L), AST activity (114.62±0.63 U/L) and TNF-α concentration (39.18±0.84 Pg/ml). But, it decreased serum albumin (2.66±0.08g/dl) and total proteins (3.54±0.05g/dl) levels. Furthermore, it reduced hepatic glutathion (GSH) (11.82±0.15nmol/g) and glutathion peroxidase (Gpx) (0.04±0.08nmol/g). It induced a increase in the expression of the pro-inflammatory cytokine (IL-1β) (53.53±0.43) with significant reduction in IL4 (53.53±0.43) in the liver homogenate. Histopathological examination of hepatic tissue revealed ballooning degeneration and hepatic damage. However, curcumin alleviated Augmentin-induced liver damage. Conclusions: These results revealed that Amoxycillin/clavulanic acid is a hepatotoxic drug in rats. Meanwhile, curcumin reverses that harmful hepatotoxic effect.
Keywords: Antibiotics, antioxidants, hepatitis, anti-inflammatory, cytokines.
( بحث فردى منشور محلى غيرمستخلص من رسالة علمية ولم يسبق تقييمه)
Protective effects of curcumin against Augmentin-induced hepatotoxicity in rats
Mona A. El Shemy1
1 Department of Clinical Pathology, Faculty of Veterinary Medicine, Benha University
Aims: Amoxycillin/clavulanic acid (Augmentin®) is an effective antibiotic which was approved by WHO as a drug for treatment of infection. Its efficacy to inhibit microorganisms had led to their increased use. There is a possibility that the drug may have potential toxic effects following consumption. So, we design this study to investigate if the Amoxycillin/clavulanic acid had toxic effects on liver or not and to explore the role of curcumin in the reduction of this toxic effect. Methods: Forty male albino rats were separated into four groups (10 rats per group); Control group, Augmentin group, curcumin group and curcumin protected group. Amoxycillin/clavulanic acid was administered at 31.83 mg/kg b.wt twice for seven days, curcumin was taken at 300 mg curcumin / kg b.wt for two weeks. Results: Amoxycillin/clavulanic acid caused a significant elevation in the level of serum malondialdehyde (53.53±0.43nmol/g). Moreover, it increased the serum ALT activity (104.87±1.01 U/L), AST activity (114.62±0.63 U/L) and TNF-α concentration (39.18±0.84 Pg/ml). But, it decreased serum albumin (2.66±0.08g/dl) and total proteins (3.54±0.05g/dl) levels. Furthermore, it reduced hepatic glutathion (GSH) (11.82±0.15nmol/g) and glutathion peroxidase (Gpx) (0.04±0.08nmol/g). It induced a increase in the expression of the pro-inflammatory cytokine (IL-1β) (53.53±0.43) with significant reduction in IL4 (53.53±0.43) in the liver homogenate. Histopathological examination of hepatic tissue revealed ballooning degeneration and hepatic damage. However, curcumin alleviated Augmentin-induced liver damage. Conclusions: These results revealed that Amoxycillin/clavulanic acid is a hepatotoxic drug in rats. Meanwhile, curcumin reverses that harmful hepatotoxic effect.
Keywords: Antibiotics, antioxidants, hepatitis, anti-inflammatory, cytokines.