Advances in technology, industry, economy and researches forced all people to continuous use of rapidly increased
application of microwave (MW) radiation especially Wireless communication systems that is used daily in telecommunication,
on line learning, medicine and even for animal farms management, these radiation uses always happen inside the buildings
such as houses, schools, hospitals, offices, farms and public places leading to the threaten people’s and animals’ health
especially vital organs and so this will reflect negatively on investment. Our study aimed to evaluate the possibility of new
trends in hepatoprotection by potentiality of some famous historical architectural shapes as a physical protector against the
harmful effects of the mobile phone radiation MPR, (900 MHz) for 8 weeks and to create healthy and high efficient architectural
environments. Thirty-six (36) Swiss Albino male mice were randomly divided into 6 groups (n = 6), they housed in 6 cages
with various shapes to assess the hepatoprotective effects of against MPR. Group I & II housed in a traditional cage, Group
I served as a control which did not subjected to mobile phone but groups (II-VI) are exposed to mobile phone radiations. Our
result revealed that these changes in architectural shapes (especially pyramid, bio-geometry and hexagonal shapes) can
decreased the elevated hepatic enzymes either serum transaminases (ALT, AST) or alkaline phosphatase (ALP) in comparison
to positive control groups and also restore the antioxidant capacity (total antioxidant (TAC), malondialdehyde (MDA) and
nitric oxide (NO), reduced glutathione (GSH), catalase (CAT) plus retain the normal hepatic architecture in histopathology, it
concluded that some specific architectural shapes may protect the liver from hazard of electromagnetic waves and this study
can be useful for architects and advised to be used in the creation of healthy architecture buildings for either human or animal
farms.