Background: Inappropriate medication dosing in patients with
chronic kidney disease can cause toxicity or ineffective therapy.
Patients are at a high risk of developing related adverse events caused
by the altered effect of drugs in conjunction with the use of
polypharmacy to treat comorbid conditions. Aim: The aim of this
work was to highlight the awareness among patients and doctors
regarding dose adjustment in chronic kidney disease. Methods: This
is cross-sectional study was carried out in Benha University hospitals
in Internal Medicine, Cardiology, Hepatology, Pulmonology, and
Neuropsychiatry Departments on different doctors and patients in the
wards using questionnaire. The questionnaire included the following
items: Demographic data, Occupational history, Education history,
and Personal/family history of kidney disease. Results: Regarding
questions asked to patients, 55% knew that patients with CKD need
dose adjustment, 14% knew drugs need to be adjusted and 9% knew percentage of drugs need to
be adjusted. Conclusions: Regarding questions asked to doctors, 97% knew that patients with
CKD need dose adjustment, 91% knew drugs need to be adjusted, 84% knew Percentage of
drugs adjusted and 66% knew level of GFR a given medication needs to be adjusted. Patients
across all levels of training demonstrated poor awareness and knowledge of individualizing
therapy based on patient‟s renal function. Poor knowledge of renal dosing rules and lack of
medication information have been identified as major causes of prescribing errors.