Background: In a randomized, double-blind, comparative, prospective study, we have evaluated the effect of magnesium sulphate on the postoperative pain relief in the lower abdominal surgery.
Methods: Ninety patients, ASA I or II status, aged from 20 to 50 years, undergoing lower abdominal surgery under general anesthesia. Classified into three equal groups, the Fentanyl group (F group) received 2 micg/kg Fentanyl, the magnesium group received 3 g (50 mg/kg) magnesium sulphate, the third group received both Fentanyl 2 micg/kg plus magnesium sulphate 3 g (50 mg/kg), Magnesium sulphate or Fentanyl added to 100 cc 0.9% saline and gave to patients i.v infusion 3o minutes before induction of anesthesia. The following parameters was recorded, MAP, HR, Serum cortisol level and blood sugar level. At the following intervals: before induction of anesthesia, after skin incision, and before skin closure. Then postoperatively the following parameters were recorded, the time to the 1st analgesic dose required, VAS, shivering scale, and postoperative hospital stay.
conclusion:The administration of IV magnesium preoperatively is effective in pain relief after lower abdominal surgery.