Evaluation of bioequivalence of two enrofloxacin formulations after intramuscular administration in goats.
Korean Journal of Veterinary Research, 2013, 53(2): 77-82. • 2013
معلومات البحث
المؤلفون
Aboubakr M
الكلمات المفتاحية
enrofloxacin, goats, bioequivalence
المجلة العلمية
Korean Journal of Veterinary Research, 2013, 53(2): 77-82.
الناشر
Not Available
المجلد
53
العدد
2
الصفحات
77-82
publication.type
International
رابط البحث
Open Link
المواد المرفقة
Not Available
الملخص
The present study was planned to evaluate the bioequivalence of two commercial formulations of enrofloxacin, which have been marketed as 10% injectable solution after intramuscular administration at a single dose of 2.5 mg/kg body weight to 12 clinically healthy goats The study was carried out on the basis of crossover design. The two formulations were: Baytril as a reference product and Spectrama Vet as a test product. The plasma concentrations of enrofloxacin were measured by high performance liquid chromatography (HPLC) with UV detector. The pharmacokinetics of that data was performed using non-compartmental analysis. The maximum plasma concentration ($C_{max}$), time to reach peak concentration ($T_{max}$), area under concentration-time curve (AUC), elimination half-life ($t_{0.5el}$) were 1.14 and $1.05{mu}g/mL$, 0.79 and 0.83 h, 5.70 and $5.79{mu}g.h/mL$, 5.19 and 5.39 h for Baytril and Spectrama Vet, respectively. The 90% confidence interval for the mean ratio of $T_{max}$, $C_{max}$ and AUC were 94.72-116.2, 87.88-97.16 and 86.44-118.72%, respectively. These values falls within the European Medicines Agency bioequivalence acceptance range of 80-125% for both $T_{max}$ and AUC and between 75-133% for $C_{max}$. In conclusion, Spectrama-Vet is bioequivalent to Baytril and both products can be used as interchangeable drug in veterinary medicine practice.
أعضاء هيئة التدريس - جامعة بنها