Cosmetic products support microbial growth due to the presence of variable amounts of nutrients. Pathogens can be reached to cosmetic products by many sources, but antibiotics-resistant bacteria are the most dangerous. Moreover, there is an urgency to look for a natural antimicrobial agent that is safer and has fewer side effects. This research was investigated antibacterial activity of S. platensis extracts against antibiotics-resistant pathogenic bacteria isolated from some cosmetic products. From microbiological analysis of collected cosmetic sample 18 pathogenic bacterial isolates possess different virulence factors (protease, rhamnolipid and hemolysin production) were obtained. Four of them high resistant to tested antibiotic and these isolates were genetically identified as Bacillus cereus, Staphylococcus sp., Pseudomonas aeruginosa and Stenotrophomonas maltophilia. Results showed that methanol and hexane extracts of S. platensis (S2) at 0.5 mg/mL were highly active against four pathogenic isolates with inhibition zone ranged between 2 ±0.5 mm to 23±0.4 mm. This result indicated that the methanol and hexane of the cyanobacteria S. platensis have the potential as a natural antibacterial agent.