أعضاء هيئة التدريس - جامعة بنها
SERUM TRIGGERING RECEPTOR EXPRESSED ON MYLOID CELLS-1 [sTREM-1] AND ITS ROLE IN DIAGNOSIS OF NEONATAL SEPSIS
• 2015
معلومات البحث
المؤلفون
Magda Zidan, Howyda M Kamal, Mona M El-behisy,Omima M. Abdel Haie, Mai Nasser
الكلمات المفتاحية
Not Available
المجلة العلمية
Not Available
الناشر
Not Available
المجلد
Not Available
العدد
Not Available
الصفحات
Not Available
publication.type
International
رابط البحث
Not Available
المواد المرفقة
Not Available
الملخص
Objective: To asses the role of Triggering receptor expressed on myeloid cells-1 (TREM-1) as a potential early diagnostic marker of neonatal sepsis.
Methods: Studied neonates were evaluated for sepsis using clinical and laboratory measures. sTREM-1 was measured in the serum by Enzyme Linked Immunosorbant Assay(ELISA)on admittion& 48 hour after antibiotic therapy.Another 10 blood samples from healthy neonates age & sex matched to cases were analysed for sTREM-1 as a control group.
Results: Baseline sTREM-1 levels were significantly elevated in septic neonates (1011.1 ± 594.93 pg/mL) compared to controls (136.6 ± 41.3 pg/mL). Septic preterm neonates had significantly higher sTREM-1 compared to full term neonates. sTREM-1 was significantly decreased 48 h after antibiotic therapy compared to baseline sTREM-1. The cutoff value of 250pg/mL could be diagnostic for neonatal sepsis(NS) with 97.1% sensitivity and90% specificity (AUC,0 .97).
Methods: Studied neonates were evaluated for sepsis using clinical and laboratory measures. sTREM-1 was measured in the serum by Enzyme Linked Immunosorbant Assay(ELISA)on admittion& 48 hour after antibiotic therapy.Another 10 blood samples from healthy neonates age & sex matched to cases were analysed for sTREM-1 as a control group.
Results: Baseline sTREM-1 levels were significantly elevated in septic neonates (1011.1 ± 594.93 pg/mL) compared to controls (136.6 ± 41.3 pg/mL). Septic preterm neonates had significantly higher sTREM-1 compared to full term neonates. sTREM-1 was significantly decreased 48 h after antibiotic therapy compared to baseline sTREM-1. The cutoff value of 250pg/mL could be diagnostic for neonatal sepsis(NS) with 97.1% sensitivity and90% specificity (AUC,0 .97).