tudy Question: The question: is there any difference in pregnancy rate between embryo transfer day 5 and day 6 in IVF? What Is Known Already?
Blastocyst transfer is increasingly popular in assisted reproductive technology
(ART) centers today. Very few articles concentrate on comparing Day 5 and
Day 6 embryo transfer with conflict results. Objective, Study Design: Systematic review and meta-analysis of published controlled studies. Searches
conducted from 2001-2020 on PubMed. Medline, EMBASE, and ISI Web of
Science Electronic database is used to collect data, using the following search
terms: blastocyst, Day 5, Day 6, embryo transfer (E.T.) and pregnancy rate.
Materials, Setting, Methods: A total of 6 full-text articles preselected from
211 references, based on title and abstract. Two independent reviewers performed data selection and extraction according to the Preferred Reporting
Items for Systematic Reviews and Meta-Analysis statement (PRISMA). This
systematic review was conducted according to (PICO) standard. Random-effect meta-analysis performed on all data (overall analysis). Results
and the Role of Chance: Data from 6 relevant articles were extracted and
integrated into the meta-analysis that reported clinical pregnancy rate (CPR)
as an outcome in 5640 cycles, 2274 cycle had embryo transfer at day 6 and the
control was 3366 cycle had embryo transfer day 5 showed a significantly
higher clinical pregnancy rate following Day 5 embryo transfer compared with
Day 6 embryo transfer with odd ratio and 95% confidence limit 0.73 (0.66 -
0.82) p value < 0.000. Sensitivity analysis led to similar results and conclusions.
Limitations, Reasons for Caution: