Recruitment and development of multiple follicles in response to gonadotrophin stimulation are the key factors leading to successful treatment by aassisted reproductive methods . Exaggerated response on the one hand leads to increased risk of ovarian hyperstimulation syndrome and multiple pregnancy . while on the other hand, poor ovarian response is associated with cancellation of the cycle and poor pregnancy rates . any modailty whch may predict ovarian responsiveness prior to ovulation induction will be helpful in counseling the patients and tailoring the dosage of gonadotrophin
Traditionally, chronological female age and early follicular phase serum FSH levels are the most useful parameters for predition of the ovarian reserve
Clinical studies suggest that a small ovarian volume and decreased number of antral follicles indicate a poor response to subsequent controlled ovarian stimulation . the total number of antral follicles achieved the best predictive value as to the ovarian response in an IVF programme, followed by basal FSH hormone
It was reported that a diminished ovarian response and a lower pregnancy rate in women with high E2 . however a non significant efficacy of E2 in predicting poor ovarian response or pregnancy rate

Basal leptin hormone could predict oocyte quality and pregnancy rate with documented success by many investigation
The aim of this was conducted to evaluate the efficacy of age , BMI , basal FSH, FSH/LH , basal serum leptin hormone , AFC and total ovarian volume in predicting the ovarian response to gonadotrophin stimulation in IVF patients.
The parents study conclded that AFC is the signal most important predictor of ovarian reserve followed by FSH . However no effect of these varibles in predicting pregnancy rate.

Age and basal leptin hormone were the best predictors of pregnancy rate however no cut off value of both of them could afford high sensitivity and specificity.