Key words:Self Management Program, mothers of children with stomas Background: Adjusting to life with an ostomy ultimately allowed children to develop skills which were perceived to promote personal growth, positive self image, and better quality of life. The pediatric nurse can be the turning point in the life of children with stoma and his family. A child can regain his self-esteem if he receive care from his mother and learn self care like toilet habits Aim: The aims were to assess mothers’ knowledge and practices regarding stoma care of their children, and to evaluate the effectiveness of self management program about stoma care on mothers of children with stoma. Sample: A purposeful sample consisted of 70 mothers of children with stoma, was recruited in this study. Design: A pre/post quazi-experimental design was adopted in this study. Sitting: The sitting was children specialized hospital at Benha city, in the pediatric surgical ward and pediatric surgery outpatient clinic. Tools: Tools for data collection were two main parts; part one had three aspects, sociodemographic data of the mothers, socio-demographic data of children with stomas and medical history of the child. Part two was questionnaire sheet to assess mothers’ knowledge and observational check list to assess mothers’ practice regarding stoma care. Results: Data results revealed that the mean age of the studied children was 16.42 ±12.71, months, about two thirds of them (66.7%) was male. The studied mothers were house wives and illiterate (82%, 64% respectively). Less than two thirds of the studied children had colostomy for Hirshsprung disease, (62.2%), and had temporary colostomy 64.4%, while 35.6% had permanent colostomy. Conclusion: The study concluded that mothers’ knowledge and practice improved after exposure to the program Recommendations: The study recommended that pediatric nurses’ role is very crucial in helping mothers of children with stomas to adapt with self care activities.