The current study was done on 54 samples of mcdicinal plants mostly used in public medicine as a treatment of kidney affections , common cold , cough and constipation these plants are Cymbopogon proximus ,Imbrosia maritime, Artmesia, Telio Ginger, Cinnamomum Nigella saliva and Cassia Senna and were collected randomly from 3 different localities in Egypt (Moshtohor ,Tukh & C airo),. The incidence and concentrations of` of mycotoxins (Ochratoxin A and Aflatoxin B I ) were determined in these plants Also , some mycotoxins producing fungi were isolated from these plants Basidiobatrys Sp. A. flavous , A. niger , A.parasiticus , A.Ochracious and Fusurium sp. ) . All samples were subjected to gamma radiation at 5 kGy to investigate the possibility of controllling mycotoxins and fungi in medicinal plants. Our results indicated that gamma radiation destroyed the majority of mycotoxins and fungi in gamma irradiated medicinal plants however , some mycotoxins and fungi still present in medicinal plants even after exposure to gamma radiation at the recommended dose We concluded that gamma radiation is a useful control method for mycotoxins and fungi in medicinal plants but other control measures either in preharvest, harvest or storage period of these plants should go hand in hand.