أعضاء هيئة التدريس - جامعة بنها
Assessment of Carcinoembryonic Antigen-Related Cell Adhesion Molecules (CEACAM6) in pancreatic ductal adenocarcinoma, a combined serum and immunohistochemical study
the medical journal of Cairo university • 2015
معلومات البحث
المؤلفون
Mostafa M. Amer (MD)*, Ghada A. Abd El-Fattah (MD)**, Mohebat H. Gouda (MD)**, Rasha M. El-Sawi (MD)**, , Ebada M. Saeed (MD)***, Ahmed Zeedan (MD)****.
الكلمات المفتاحية
Chronic pancreatitis (CP), Pancreatic ductal adenocarcinoma (PDAC), Carcinoembryonic antigen-related cell adhesion molecule-6 (CEACAM6).
المجلة العلمية
the medical journal of Cairo university
الناشر
Not Available
المجلد
Not Available
العدد
Not Available
الصفحات
Not Available
publication.type
International
رابط البحث
Not Available
المواد المرفقة
Not Available
الملخص
ABSTRACT
Background: Pancreatic cancer is a disease with an extremely poor prognosis. Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is emerging as an important determinant of the malignant phenotype in a range of cancers, including pancreatic cancer. Therefore, the aim of this study was to evaluate the potential involvement of CEACAM6 in the development, invasion and metastasis of pancreatic cancer cells.
Patients & Methods: This prospective study included 7 cases of chronic pancreatitis and 25 cases of pancreatic duct adenocarcinoma, which were collected from General Surgery Department, Faculty of Medicine, Benha University and Egyptian National Cancer Institute (NCI), in the period 2010-2014. Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) immunohistochemical staining and soluble CEACAM6 were estimated in all cases and the pattern of expression in tissue was analyzed.
Results: Eighty eight percent of pancreatic ductal adenocarcinoma cases were positive for CEACAM6, while only 14.3% of chronic pancreatitis were positive, which was statistically significant (p
Background: Pancreatic cancer is a disease with an extremely poor prognosis. Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is emerging as an important determinant of the malignant phenotype in a range of cancers, including pancreatic cancer. Therefore, the aim of this study was to evaluate the potential involvement of CEACAM6 in the development, invasion and metastasis of pancreatic cancer cells.
Patients & Methods: This prospective study included 7 cases of chronic pancreatitis and 25 cases of pancreatic duct adenocarcinoma, which were collected from General Surgery Department, Faculty of Medicine, Benha University and Egyptian National Cancer Institute (NCI), in the period 2010-2014. Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) immunohistochemical staining and soluble CEACAM6 were estimated in all cases and the pattern of expression in tissue was analyzed.
Results: Eighty eight percent of pancreatic ductal adenocarcinoma cases were positive for CEACAM6, while only 14.3% of chronic pancreatitis were positive, which was statistically significant (p