Background: Pressure ulcers are a prevalent health condition that presents a nursing and social
strain. The risk of death is two to six times higher in a patient with a pressure ulcer than in
those with intact skin. Aim: assessing the influence of applying evidence-based practices guidelines
on immobilized orthopedic Patients' Outcome regarding Pressure Ulcers. Method: This study was
done at Benha University Hospital's orthopaedic unit utilizing a quasi-experimental research
approach. This research enrolled a purposive sample of sixty adult patients. , divided equally into
study and control groups. Two tools were employed for collecting data. Tool I; Comprehensive skin
assessment sheet and tool II; Braden Risk Assessment Scale. Results: There was a statistically
significant variation in patients' Outcomes regarding pressure ulcers following application of
evidence-based practises guidelines between the study and control groups. Otherwise, orthopedic
immobilized patients receiving standard nursing care developed multiple and advanced stages of
pressure ulcers. Conclusion: Implementation of evidence-based practice guidelines significantly
improved orthopedic immobilized patients' outcome regarding pressure ulcers as compared to
orthopedic immobilized patients receiving normal nursing care. Recommendations: Pressure ulcer
prevention in accordance with evidence-based practises guidelines should be successfully applied
for orthopedic immobilized patients who are at risk of having pressure ulcers.