Objectives:To determine the frequency ofHelicobacterpylori(Hp)infection among
primigravidaanditsrelationtodevelopmentofpreeclampsia(PE)
Patients&Methods:Thiscohortstudyincluded146primigravidaevaluatedpriortothe12th
weekgestationalage,womenwhodevelopedPEwerecategorizedasPEgroupandasimilar
numberofpregnantwomenfreeofhypertensivemanifestationsascontrol(NoPE)group.All
patientswereevaluatedforageandbodymassindex(BMI)andunderwentHpdiagnosis
workupincludingUreabreathtestandHpstoolantigentesting.
Results:Twenty-sixwomendevelopedearlyand47developedlatePEand52hadmild,while
21hadseverePE.DevelopmentandseverityofPEshowedpositivesignificantcorrelation
withBMI.SixtypatientswereHp+;bloodpressuremeasuresattimeofdevelopmentofPE
weresignificantlyhigherinHp+thaninHp-patients,irrespectiveofdevelopingPE.Blood
pressure measures and BMIshowed positive significantcorrelation with Hp positivity.
StatisticalanalysisdefinedhighBMIasthesignificantindependentpredictorfordevelopment
ofPE.
Conclusion:HighBMImayunderliethedevelopmentandseverityofPEandisassociatedwith
Hpinfection