The present study was conducted to explore the effects of some factors affecting the productive and economic efficiency of Hy-Line layer breed in El-Menofia governorate. Data was collected from accurate records present in the farms and from structural questionnaire method during period from 2000 to 2018 on 29 cycles. The aim of this study is to determine and highlight the most important factors affecting the productive efficiency of Hy-Line breed and their profitability under Egyptian conditions. The study revealed that forced molting had a significant effect (P