Recently, psychiatric health is considered a unique scope in promoting rights of patient safety, although there are few scientific researches that provide information about patient safety frameworks, coaching, politics and providing suitable patient care without harm Aim: this study aimed to assess the relation between patient safety and organizational culture inpatient care at psychiatric hospitals. Design: descriptive correlational design. Setting: This study was carried out at Mansoura & Benha Psychiatric hospital. Sample: All nurses worked at the studied hospitals. Tools: two tools were used, WHO Medical School Curricular Guide for Patient Safety and Organizational Culture Assessment Instrument. Results: there is a highly significant positive correlation between patient safety and organizational culture at both Psychiatric hospitals. Conclusion: There are other factors rather than Organizational culture affects patient safety as patients, physical environment, and care provider factors. Recommendation: Develop patient safety culture as an important part from organizational culture.