In this prospective, randomized, double-blind study, we compared the incidence and severity of painful injection of propofol. One hundred ASA I, II patients scheduled for elective surgery under general anesthesia were recruited into this study. The patients were randomized into four groups each 25 patients. Group A (placebo) receives 2ml saline before propofol, group B receives 2mL lignocaine 2% before propofol, group C receives propofol mixed with 2mL lignocaine 2% and group D receives 10mg metoclopramide before propofol. The incidence of pain was less in patients pretreated with lignocaine (group B) 32% (p0.01), patients of lignocaine mixed with propofol (group C) 28% (p