Background: Acne vulgaris (AV) is an inflammatory skin disorder that may be associated
with metabolic disorders. The relation between lipid profile in acne is not widely
investigated. Chitinase‐3‐like protein 1 (YKL‐40) has been found to be implicated in
different inflammatory conditions.
Aims: We aimed at investigating the role YKL‐40 in acne pathogenesis and associated
dyslipidemia in acne patients.
Patients/Methods: This study included 50 acne vulgaris patients and 30 matched
control subjects. Serum YKL‐40 in addition to lipid profile were assessed in all studied
subjects.
Results: Serum YKL‐40 level was significantly elevated in acne patients than healthy
controls (P < .001). We also found a significant positive correlations between serum
YKL‐40, serum TGs, TC, and LDL‐C (P value: .022, .001, .017 respectively) while, a
significant negative correlation between serum YKL‐40 and HDL‐c (P value: .036)
was detected.
Conclusion: Our study results suggest that YKL‐40 might have a role in AV pathogenesis.
In addition, it could provide a new potential link between inflammation and
dyslipidemia observed in acne patients.