In the recent years, the big challenge which faces the world is the lack of vaccines and drugs for viruses which appeared widely with different families and serotypes, especially RNA viruses. The high mutation and instability nature of RNA viruses prevent the long life affect of the vaccines, for this reason a lot of researches in RNA viruses structure and function have been conducted to overcome this challenge. The deep understanding of the virus in its life cycle, genome sequencing, second and tertiary structure of the virus affect positively in solving the addressed problem. This paper focuses on foot-and-mouth disease virus (FMDV) which is considered one of the most popular viruses in picornafamily, that is belonging to RNA viruses' class, To be more accurate the paper concerned in IRES region only, which is crucial to exploring and deciphering the initiation mechanism of translation and replication of the virus. It is notable that: the most researches in this area have been conducted in vitro, and few researches in computational. This paper introduce a survey for the computational efforts in IRES region of FMDV and suggests some novel research points which can be investigate in future.