A new simple, accurate, precise and sensitive indirect method for the determination of chlorphenramine maleate (CPRM)and chlorphenoxamine HCl (CPX HCl) using AAS has been developed. The method is based on precipitation of the ion associates formed by the reaction of CPRM or CPX HCl with ammonium reineckate and /or sodium cobaltinitrite. The solubility of the solid complexes at the optimum conditions of pH and ionic strength values have been studied. Saturated solutions of each ion associate were prepared under the optimum conditions and the metal ion- content in the supernatant was determined. The method has been used for the determination of 15.6 -156.4 and 13.6 – 136.1 µg/mL of CPRM and CPX respectively. The method developed was applied for the analysis of bulk drugs and some of thier pharmaceutical preparations.


Analusis, 24, 139–142 (1996).