The polarographic behaviour of the degradation product of ampicillin formed by alkaline hydrolysis is studied at different pH values. In strong alkaline solution (pH = 12) it gives two reduction waves with half-wave potentials -0.62 and -1.35 V vs. SCE. The first wave (at -0.62 V) is used for analytical purposes. A new and sensitive method is described for analytical determination of ampicillin in its pharmaceutical formulation and human urine.
Analytical Letters 01/1994; 27(1532-236X):2515-2521.