In this study, evaluation and performance investigation of new three different configurations, for sea water desalination system using two identical Ranque-Hilsch vortex tubes (RHVT) is carried out. The new technique for water desalination is developed using various series and parallel vortex tubes configurations, instead of single vortex tube integrated desalination system, two series RHVTs using the hot air stream of the first tube as the air source of the second one is called series hot vortex tubes (SHVT) configuration, another configuration was two series RHVTs using the cold air steam of the first tube as the air source of the second one, is called series cold vortex tubes (SCVT) configuration, the third one was two parallel RHVTs collecting both hot air steams of the two tubes from one side and collecting both cold air steams of the two tube from the other side, and is called parallel vortex tubes (PVT) configuration. The main study conclusions are deduced that, the desalinated water quantity reached about 79% of the initial sea water quantity for SHVT arrangement, otherwise, it was about only 70% for SCVT arrangement and 74% for PVT arrangement. Furthermore, the results of this work could help to adopt more efficient desalination systems based on using RHVTs, and the SHVT configuration can be strongly recommended for use in seawater desalination.