Background and objectives Postoperativepainafterlaparoscopiccholecystectomy(LC)isunpredictable,which explains the need for systematic prevention of pain before the patient wakes up from anesthesia. The study was conducted to evaluate the effect of intraperitoneal levobupivacaine with or without sufentanil for postoperative analgesia after LC. Patients and methods Ninety patients who underwent elective LC completed the study. Group C (n=29) received 50ml of intraperitoneal normal saline, group L (n=31) received 50ml of intraperitoneal levobupivacaine 0.25%, and group LS (n=30) received 50ml of intraperitoneal levobupivacaine 0.25% plus 20μg sufentanil. Visual analog score wasrecordedimmediatelypostoperatively,andat4,8,and12hpostoperatively.In addition, time to first rescue analgesia (diclofenac), total diclofenac consumption in 12h, and complications (pruritus, emesis, shoulder pain, bradycardia, and hypotension) were recorded. Results Visual analog score until 8h postoperatively was significantly higher in group C compared with groups L and LS. However, the difference was nonsignificant between groups L and LS, except at 8 and 12h postoperatively. Time to first rescueanalgesiawassignificantlylongeringroupLS(134.16±36.5)comparedwith group C (11.96±5.92) and group L (114.83±35.49) (P