Objectives: We aimed to evaluate serum levels of Heart-type fatty acid binding protein (H-FABP) during seizures compared to their interictal levels and healthy controls and changes in heart rate (HR) and HR variability in epileptic children with intractable seizures. Methods: We included 30 epileptic seizures in 25 children with intractable epilepsy and 30 matched controls. They were subjected to: Video-EEG monitoring simultaneously with Holter ECG and measurement of H-FABP. Results: Mean serum levels of H-FABP were increased significantly in patients either in the ictal or interictal periods compared to that in the controls (P-value