Epoxide derivative II was used to synthesize a number of new condensed and noncondensed
heterocyclic systems. Thus, reaction of II with amines, hydrazines, active methylene compounds
and Friedel—Crafts reactions have been studied. On the other hand, II reacted with Grignard
reagents and afforded products with an open epoxide ring. However, II condensed with thiourea
and glycine gave oxazolinethione and 2-morpholinone derivatives. Also, II reacted with acetic acid
and gave hydroxypropanoyl derivative. Action of different nitriles with II gave the hydroxy amide
derivatives, which underwent cyclization and afforded 2-oxazoline derivatives.