Introduction: Acute kidney injury has a high morbidity and mortality outcome so need highly sensitive
marker to assess the degree of tubular affection for early detection and management to prevent further complication.
Methods: We investigated the ability of a furosemide stress test (FST) (one-time dose of 1.0 or1.5 mg/kg depending
on prior furosemide-exposure) to predict the development of AKIN Stage-III in critically ill subjects with early AKI
which considered group I. and group II who received standard management for AKI. Result: We studied 80
subjects; 40 consecutive patients in group I and 40 consecutive patients in group II; 25 (37.5%) and (50%) met the
primary endpoint of progression to AKIN-III in group I, II consequently. patients with progressive AKI had
significantly lower urine output following FST in the first 6 hours (p