-r,o elucidale the ro(e of T lymphocyte activation alld eosinophilic infiltratioll in the br~nchial tree ofpa" flellts II.'/flt /Jrollchwl asthma and the effect of salbutamol and anhydrous theophy/lllle on. these pa! milleu:rs, ([ study II'C/.· carried out on twenty patients havillg extrinsic {(sthma (group I), IIventy lVith ill,I Iril/sic 0.111/11/0 (group II) alld ten healthy controls (group 11/). Soluble Interleukin-2 receptors (sIL-2RJ. ': eosilloplii!ic counl bOlh in bronchoalveolar lavage (BAL) and blood lVere performed immediwely ajlt'!':! (he relief of acU(u allack and olle week laler during remission'. Physiologic parameters including FEV I, : FIIC and PEFR were also done during acute affack and 20 minutes afler inhalation of nebulized sal:1 bl/lal1lol. Each group ofasthmatic patients were divided into rwo subgroups. group fa and group lIa reqceived salbulamol and group Ib and group lib received anhydrous theophylline. The mean serum and dBAL sl/.-2R alld eosinophilic COUllt lVere significantly hig/ler in acute episode of asthma compared to
;1 /Jorllla! cOlllrols, moreover. there was a positive correlation between sIL-2R and eosinophilic count with ,I (III illl'erse relatiollship Ivith PEFR. Seven days afler the acute affack. palients received salbutamol did
I
not .·ho\, OilY significGlI1 decrease ill eilher sIL-2R or eosillophilic count in BALfluid and blood. on the olher h(llld siglllficallt reductio/l lI'a.l' obscn'ed ill patient,\' reeeh'ing anhydrous theophyllille. Therefore. il cOlild be concluded Ihat T cell aclivation with increas('d £'osinophilic infiltration in bronchia! free lIIay lead to enhanced bronchial hyperreactivity in patients l1'i,"',l;rollchial asthma. anhydrous theophyllille possesses antiillflammatory aClioll by virtue of its inhibitory effect on T lymphocyte activation IFhich might recolllmend ils IOi1g term use in asthmatic patients.
: Forced Expiratory Volume in the firs! second.
11 FEV,
:
FVC : Forced Vital Capacity.
;1 II PEFR : Peak Expiratory Flow Rate