This study compared between oral cabergoline and rectal bromocriptine in the treatment of female patients suffering from. This study was conducted on 220 female patients suffering from hyperprolactinemia with whose serum prolactin level above 25 ng/ml. A detailed history taking, clinical examination and serum prolactin level were done to all participants. patients were divided into two groups in a randomized pattern; group (a), included 110 patients were treated with 2.5 mg bromocriptine rectally daily once up to 3 months.; group (b), included 110 patients were treated with oral cabergoline.1/2 tablet twice a week up to 3 months. Prolactin level was assayed before treatment then after 4 weeks and 4 months respectively, comparing prolactin level pre- and post-treatment, there was significant decrease in prolactin level after treatment in Bromocriptine group (mean prolactin= 16.5 versus 40, p