This chapter investigates the multi-switching combination synchronization of three non-identical chaotic systems via active control technique. In recent years, some advances have been made with the idea of multi-switching combination synchronization. The different states of the master systems are synchronized with the desired state of the slave system in multi-switching combination synchronization scheme. The relevance of such kinds of synchronization studies to information security is evident in the wide range of possible synchronization directions that exist due to multi-switching synchronization. Numerical simulations justify the validity of the theoretical results discussed.