Computational intelligence provides the biomedical domain by a significant support. The application of machine learning techniques in medical applications have been evolved from the physician needs. Screening, medical images, pattern classification, prognosis are some examples of health care support systems. Typically medical data has its own characteristics such as huge size and features, continuous and real attributes that refer to patients’ investigations. Therefore, discretization and feature selection process are considered a key issue in improving the extracted knowledge from patients’ investigations records. In this paper, a hybrid system that integrates Rough Set (RS) and Genetic Algorithm (GA) is presented for the efficient classification of medi - cal data sets of different sizes and dimensionalities. Genetic Algorithm is applied with the aim of reducing the dimension of medical datasets and RS decision rules were used for efficient classification. Furthermore, the proposed system applies the Entropy Gain Information (EI) for discretization process. Four biomedical data sets are tested by the proposed system (EI-GA-RS), and the highest score was obtained through three different datasets. Other different hybrid techniques shared the proposed technique the highest accuracy but the proposed system preserves its place as one of the highest results systems four three different sets. EI as discretization technique also is a common part for the best results in the mentioned datasets while RS as an evaluator realized the best results in three different data sets.