أعضاء هيئة التدريس - جامعة بنها
DBU-Catalyzed transprotection of N-Fmoc-cysteine di- and tripeptides into S-Fm-cysteine di- and tripeptides.
Org. Biomol. Chem • 2010
معلومات البحث
المؤلفون
Alan R. Katritzky, Nader E. Abo-Dya, Abdelmotaal Abdelmajeid, Srinivasa R. Tala, M. S. Amine and
الكلمات المفتاحية
Not Available
المجلة العلمية
Org. Biomol. Chem
الناشر
Not Available
المجلد
9
العدد
(2)
الصفحات
596–599
publication.type
International
رابط البحث
Not Available
المواد المرفقة
Not Available
الملخص
The transprotection of N-Fmoc-cysteine containing di- and tripeptides possessing a free SH group to
produce the corresponding S-Fm-cysteine di- and tripeptides bearing a free amino group is accomplished efficiently with DBU in dry THF. The N-Fmoc to S-Fm transformation mechanism is discussed.
S-Fm-Cysteine di- and tripeptides readily form amide bonds on coupling with N-(Pg-a-aminoacyl)-
benzotriazoles and N-(Pg-a-dipeptidoyl)benzotriazoles to give larger peptides.
produce the corresponding S-Fm-cysteine di- and tripeptides bearing a free amino group is accomplished efficiently with DBU in dry THF. The N-Fmoc to S-Fm transformation mechanism is discussed.
S-Fm-Cysteine di- and tripeptides readily form amide bonds on coupling with N-(Pg-a-aminoacyl)-
benzotriazoles and N-(Pg-a-dipeptidoyl)benzotriazoles to give larger peptides.