Abstract Current treatment of endometriosis is mainly based on surgery and ovarian suppressive
agents (oral contraceptives, progestins, GnRh agonist and androgenic agents). Hormonal treatments
are often associated with unwanted effects, delayed conception and recurrence of disease
and symptoms when stopped. For these reasons, new drugs that aim new targets are required to
cause regression of the disease & symptoms without adverse hypo-estrogenic effects. This review
aims to provide an update on the new drugs used for treatment of endometriosis. These include
the levonorgestrel-releasing intrauterine device, GnRH antagonists, aromatase inhibitors, selective
estrogen-receptor modulators, progesterone antagonist, selective progesterone receptor modulators,
angiogenesis inhibitors, and immunomodulatory drugs.