Myocardial infarction (MI) is an irreversible injury or subsequent necrosis of myocardial cells due to interruption of blood supply to a part of the heart.The present study was designed to compare the benificial therapeutic effects of nebivolol and lisinopril on the progression of myocardial infarction in a rat model of isoprenaline induced acute myocardial infarction. Animals were classified intonormal control group (received normal saline), Myocardial infarcted group (s.c injection ofisoprenaline at a dose of 150mg/kg/day diluted in 2ml of saline on two consecutive days with an interval of 24 hours between application, Nebivolol treated infarcted group(0.5mg/kg p.o.) once daily for 4 weeks after induction of MI, Lisinopril treated infarcted group (20mg/kg p.o.) once daily for 4 weeks after induction of MI. The obtained results in the current work revealed that induction of myocardial infarction by isoprenaline resulted in significant increase heart rate, decrease mean arterial blood pressure and increase T-wave voltageat the end of the study, while administration of nebivolol and lisinopril to myocardial infarcted rats for 4 weeks resulted in decrease of heart rate, decrease mean arterial blood pressure, decrease in T-wave voltageand improved histopathological changes of heart as compared to infarcted untreated rats. Administration of Nebivolol and lisinopril immediately afteroccurance of acute myocardial infarction prevent progression of the disease and improve pathological changes occurred in the heart.