Background: Bisphenol A (BPA) is an endocrine disrupting chemical that predisposes to reproductive toxicity due
to its oxidative stress. Selenium (Se), found in cereals, fish, and meat and has antioxidant properties. The aim of this
work is to investigate the harmful effect of exposure to BPA on the testes of adult male albino rats and the protective
effect of Se. Material& methods: This study included 40 adult male albino rats were divided equally into 4 groups:
Group I (control group) It received distilled water once daily by gastric tube for 4 weeks. Group II (Selenium group) It
received 10 μg Se /kg bw/day; administered orally via gastric tube for 4 weeks. Group III (BPA group) It received 10
μg BPA /kg bw/day; administered orally via gastric tube for 4 weeks. Group IV (BPA+Se group) It received 10 μg
BPA/kg bw/day followed by 10 μg Se /kg bw/day. Both administered orally via gastric tube for 4 weeks. The sections
of testis were stained with Hematoxylin & Eosin and Masson’s Trichrome stains, Also Immunohistochemical study was
done to detect BCL2. RESULTS: The study had demonstrated that BPA caused degeneration in the seminiferous
epithelium and in the interstitium, dilitation and congestion of the blood vessels, and increased of the collagen fibers in
the interstitium . Immunohistochemical results showed a decrease in the expression of the antiapoptotic protein
(Bcl2).Selenium administration caused significant improvement in the histological structure of the testis. Conclusion:
selenium protects the testis from the toxic effect of Bisphenol A.